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Handbook of Drug Screening, Vol 114~tqw~ darksiderg
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Handbook of Drug Screening, Vol. 114
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General Information
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Type.................: Ebook
Part Size............: 9,101,752 bytes
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Posted by............: ~tqw~
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Release Notes
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A presentation of screening techniques, modern technologies, and high-capacity
instrumentation for increased productivity in the development and discovery of
new drugs, chemical compounds, and targeted delivery of pharmaceuticals. It
contains practical applications and examples of strategies in cell-based and
cell-free screens as well as homogeneous, fluorescence, chemiluminescence, and
radioactive-based technologies.
Table of Contents
Preface
Contributors
1 Moving Into the Third Millennium After a Century of Screening 1
2 Basic Considerations in Designing High-Throughput Screening Assays 5
3 Screening Platforms 31
4 Homogeneous Assays for High-Throughput and Ultrahigh-Throughput
Screening 69
5 Microbe-Based Screening Systems 129
6 Molecular Genetic Screen Design for Agricultural and Pharmaceutical
Product Discovery 153
7 Receptor Screens for Small Molecule Agonist and Antagonist Discovery
189
8 Functional Assay Screens 265
9 Enzyme Screens 283
10 Screening Strategies for Ion Channel Targets 313
11 High-Throughput Screening Assays for Detection of Transcription 335
12 Screening of Combinatorial Biology Libraries for Natural Products
Discovery 357
13 Higher-Throughput Screening Assays With Human Hepatocytes for
Hepatotoxicity, Metabolic Stability, and Drug-Drug Interaction Potential
383
14 High-Throughput Screening for Metabolism-Based Drug-Drug Interactions
403
15 The ATCG of Drug Discovery 415
16 Genomics/Functional Proteomics for Identification of New Targets
433
17 Bioinformatics: Identification of Novel Targets and Their
Characterization 447
18 The Evolution of Laboratory Automation 477
19 Robotics and Automation 493
20 Assay Miniaturization: Developing Technologies and Assay Formats 525
21 Screening in the NanoWorld: Single-Molecule Spectroscopy and
Miniaturized High-Throughput Screening 563
Index 583
Product Details
* ISBN: 0824705629
* ISBN-13: 9780824705626
* Format: Hardcover, 520pp
* Publisher: CRC Press
* Pub. Date: January 2001
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