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Handbook of Molecular Force Spectroscopy~tqw~ darksiderg

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Handbook of Molecular Force Spectroscopy
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Type.................: Ebook
Part Size............: 11,647,466 bytes




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Posted by............: ~tqw~

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Release Notes
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Modern materials science and biophysics are increasingly focused on studying and
controlling intermolecular interactions on the single-molecule level. Molecular
force spectroscopy was developed in the past decade as the result of several
unprecedented advances in the capabilities of modern scientific instrumentation,
and defines a number of techniques that use mechanical force measurements to
study interactions between single molecules and molecular assemblies in chemical
and biological systems. Examples of these techniques, which typically target a
specific range of experimental systems and geometries, include atomic force
microscopy, optical tweezers, surface forces apparatus, and magnetic tweezers.

With contributions by internationally renowned scientists, Handbook of Molecular
Force Spectroscopy is a comprehensive, state-of-the-art review of modern force
spectroscopy, including fundamentals of intermolecular forces, technical aspects
of the force measurements, and practical applications. The Handbook presents
reviews of fundamental physical concepts of loading single and multiple chemical
bonds on the nanometer scale, covers practical aspects of modern single-molecule
level techniques, and describes several representative applications of force
spectroscopy to the study of chemical and biological processes. Computer
modeling of force spectroscopy experiments is addressed as well. In sum, this
volume is an authoritative guide to planning, understanding, and analyzing
modern molecular force spectroscopy experiments with an emphasis on biophysical
research.

Table Of Contents

Preface v
Contributors xi
1. Surface Force Apparatus Measurements of Molecular Forces in Biological
Adhesion 1
2. Force Spectroscopy with Optical and Magnetic Tweezers 23
3. Chemical Force Microscopy Nanoscale Probing of Fundamental Chemical
Interactions 97
4. Chemical Force Microscopy: Force Spectroscopy and Imaging of Complex
Interactions in Molecular Assemblies 123
5. Dynamic Force Spectroscopy with the Atomic Force Microscope 143
6. Simulation in Force Spectroscopy 163
7. Tip Functionalization: Applications to Chemical Force Spectroscopy 185
8. The Dynamical Response of Proteins Under Force 205
9. Counting and Breaking Single Bonds: Dynamic Force Spectroscopy in Tethered
Single Molecule Systems 251
10. Direct Mapping of Intermolecular Interaction Potentials 273
Index 287

Product Details

* ISBN: 0387499873
* ISBN-13: 9780387499871
* Format: Hardcover, 291pp
* Publisher: Springer-Verlag New York, LLC
* Pub. Date: December 2007

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